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Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin.

Identifieur interne : 003546 ( Main/Exploration ); précédent : 003545; suivant : 003547

Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin.

Auteurs : Stefan Zeuzem ; Ira M. Jacobson ; Tolga Baykal ; Rui T. Marinho ; Fred Poordad ; Marc Bourlière ; Mark S. Sulkowski ; Heiner Wedemeyer ; Edward Tam ; Paul Desmond ; Donald M. Jensen ; Adrian M. Di Bisceglie ; Peter Varunok ; Tarek Hassanein ; Junyuan Xiong ; Tami Pilot-Matias ; Barbara Dasilva-Tillmann ; Lois Larsen ; Thomas Podsadecki ; Barry Bernstein

Source :

RBID : pubmed:24720679

Descripteurs français

English descriptors

Abstract

In this phase 3 trial we evaluated the efficacy and safety of the interferon-free combination of ABT-450 with ritonavir (ABT-450/r), ombitasvir (also known as ABT-267), dasabuvir (also known as ABT-333), and ribavirin for the retreatment of HCV in patients who were previously treated with peginterferon-ribavirin.

DOI: 10.1056/NEJMoa1401561
PubMed: 24720679


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<nlm:affiliation>From Johann Wolfgang Goethe University, Frankfurt am Main (S.Z.), and Medizinische Hochschule Hannover, Hannover (H.W.) - both in Germany; Weill Cornell Medical College, New York (I.M.J.), and Premier Medical Group of the Hudson Valley, Poughkeepsie (P.V.) - both in New York; AbbVie, North Chicago (T.B., J.X., T.P.-M., B.D.-T., L.L., T.P., B.B.), and Center for Liver Diseases, University of Chicago Medical Center, Chicago (D.M.J.) - both in Illinois; Centro Hospitalar de Lisboa Norte and Medical School of Lisbon, Lisbon, Portugal (R.T.M.); Texas Liver Institute, University of Texas Health Science Center, San Antonio (F.P.); Hôpital Saint Joseph, Marseille, France (M.B.); Johns Hopkins University, Baltimore (M.S.S.); Liver and Intestinal Research Centre, Vancouver, BC, Canada (E.T.); St. Vincent's Hospital (Melbourne), Fitzroy, Australia (P.D.); Saint Louis University, St. Louis (A.M.D.); and Southern California Liver Centers and Southern California Research Center, Coronado (T.H.).</nlm:affiliation>
<wicri:noCountry code="subField">Coronado (T.H.).</wicri:noCountry>
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<nlm:affiliation>From Johann Wolfgang Goethe University, Frankfurt am Main (S.Z.), and Medizinische Hochschule Hannover, Hannover (H.W.) - both in Germany; Weill Cornell Medical College, New York (I.M.J.), and Premier Medical Group of the Hudson Valley, Poughkeepsie (P.V.) - both in New York; AbbVie, North Chicago (T.B., J.X., T.P.-M., B.D.-T., L.L., T.P., B.B.), and Center for Liver Diseases, University of Chicago Medical Center, Chicago (D.M.J.) - both in Illinois; Centro Hospitalar de Lisboa Norte and Medical School of Lisbon, Lisbon, Portugal (R.T.M.); Texas Liver Institute, University of Texas Health Science Center, San Antonio (F.P.); Hôpital Saint Joseph, Marseille, France (M.B.); Johns Hopkins University, Baltimore (M.S.S.); Liver and Intestinal Research Centre, Vancouver, BC, Canada (E.T.); St. Vincent's Hospital (Melbourne), Fitzroy, Australia (P.D.); Saint Louis University, St. Louis (A.M.D.); and Southern California Liver Centers and Southern California Research Center, Coronado (T.H.).</nlm:affiliation>
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<name sortKey="Marinho, Rui T" sort="Marinho, Rui T" uniqKey="Marinho R" first="Rui T" last="Marinho">Rui T. Marinho</name>
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<name sortKey="Di Bisceglie, Adrian M" sort="Di Bisceglie, Adrian M" uniqKey="Di Bisceglie A" first="Adrian M" last="Di Bisceglie">Adrian M. Di Bisceglie</name>
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<name sortKey="Pilot Matias, Tami" sort="Pilot Matias, Tami" uniqKey="Pilot Matias T" first="Tami" last="Pilot-Matias">Tami Pilot-Matias</name>
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<name sortKey="Dasilva Tillmann, Barbara" sort="Dasilva Tillmann, Barbara" uniqKey="Dasilva Tillmann B" first="Barbara" last="Dasilva-Tillmann">Barbara Dasilva-Tillmann</name>
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<title level="j">The New England journal of medicine</title>
<idno type="eISSN">1533-4406</idno>
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<date when="2014" type="published">2014</date>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Anilides (adverse effects)</term>
<term>Anilides (therapeutic use)</term>
<term>Antiviral Agents (adverse effects)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Carbamates (adverse effects)</term>
<term>Carbamates (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Drug Combinations</term>
<term>Female</term>
<term>Hepacivirus (genetics)</term>
<term>Hepacivirus (isolation & purification)</term>
<term>Hepatitis C, Chronic (drug therapy)</term>
<term>Hepatitis C, Chronic (virology)</term>
<term>Humans</term>
<term>Macrocyclic Compounds (adverse effects)</term>
<term>Macrocyclic Compounds (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>RNA, Viral (isolation & purification)</term>
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<term>Ribavirin (therapeutic use)</term>
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<term>Sulfonamides (adverse effects)</term>
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<term>Uracil (adverse effects)</term>
<term>Uracil (analogs & derivatives)</term>
<term>Uracil (therapeutic use)</term>
<term>Viral Load</term>
<term>Young Adult</term>
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<term>Anilides (effets indésirables)</term>
<term>Anilides (usage thérapeutique)</term>
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<term>Antiviraux (usage thérapeutique)</term>
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<term>Hepacivirus (génétique)</term>
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<term>Hépatite C chronique (virologie)</term>
<term>Jeune adulte</term>
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<term>Ribavirine (usage thérapeutique)</term>
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<term>Sulfonamides (usage thérapeutique)</term>
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<term>RNA, Viral</term>
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<front>
<div type="abstract" xml:lang="en">In this phase 3 trial we evaluated the efficacy and safety of the interferon-free combination of ABT-450 with ritonavir (ABT-450/r), ombitasvir (also known as ABT-267), dasabuvir (also known as ABT-333), and ribavirin for the retreatment of HCV in patients who were previously treated with peginterferon-ribavirin.</div>
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<name sortKey="Baykal, Tolga" sort="Baykal, Tolga" uniqKey="Baykal T" first="Tolga" last="Baykal">Tolga Baykal</name>
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<name sortKey="Bourliere, Marc" sort="Bourliere, Marc" uniqKey="Bourliere M" first="Marc" last="Bourlière">Marc Bourlière</name>
<name sortKey="Dasilva Tillmann, Barbara" sort="Dasilva Tillmann, Barbara" uniqKey="Dasilva Tillmann B" first="Barbara" last="Dasilva-Tillmann">Barbara Dasilva-Tillmann</name>
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<name sortKey="Di Bisceglie, Adrian M" sort="Di Bisceglie, Adrian M" uniqKey="Di Bisceglie A" first="Adrian M" last="Di Bisceglie">Adrian M. Di Bisceglie</name>
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<name sortKey="Larsen, Lois" sort="Larsen, Lois" uniqKey="Larsen L" first="Lois" last="Larsen">Lois Larsen</name>
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<name sortKey="Podsadecki, Thomas" sort="Podsadecki, Thomas" uniqKey="Podsadecki T" first="Thomas" last="Podsadecki">Thomas Podsadecki</name>
<name sortKey="Poordad, Fred" sort="Poordad, Fred" uniqKey="Poordad F" first="Fred" last="Poordad">Fred Poordad</name>
<name sortKey="Sulkowski, Mark S" sort="Sulkowski, Mark S" uniqKey="Sulkowski M" first="Mark S" last="Sulkowski">Mark S. Sulkowski</name>
<name sortKey="Tam, Edward" sort="Tam, Edward" uniqKey="Tam E" first="Edward" last="Tam">Edward Tam</name>
<name sortKey="Varunok, Peter" sort="Varunok, Peter" uniqKey="Varunok P" first="Peter" last="Varunok">Peter Varunok</name>
<name sortKey="Wedemeyer, Heiner" sort="Wedemeyer, Heiner" uniqKey="Wedemeyer H" first="Heiner" last="Wedemeyer">Heiner Wedemeyer</name>
<name sortKey="Xiong, Junyuan" sort="Xiong, Junyuan" uniqKey="Xiong J" first="Junyuan" last="Xiong">Junyuan Xiong</name>
<name sortKey="Zeuzem, Stefan" sort="Zeuzem, Stefan" uniqKey="Zeuzem S" first="Stefan" last="Zeuzem">Stefan Zeuzem</name>
</noCountry>
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Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024